Change and clinical significance of plasma D-dimer,blood coagulation and platelet in children with sepsis

Objective To study the clinical significance of D-dimer,blood coagulation of prothrombin time,activated partial thromboplastin time,thrombin time,fibrinogen and platelet counts,and provide scientific reference for the treatment of sepsis in coagulopathy.Methods Fifty-one patients with sepsis in Intensive Critical Unit were collected in this study,30 cases were ordinarily infected in general ward and 20 were healthy children.Homologous adjunctive examina ination was done according to the different disease.D-dimer,blood coagulation of prothrombin time,activated partial thromboplastin time,thrombin time,fibrinogen and platelet countswere detected immediately since patients were certified in our study.Results(1) The plasma D-dimer level of the sepsis group was higher.There was significant difference among the sepsis,severe sepsis and multiple organ dysfunction syndrome,it became much higher with the severe illness.There was a negative correlation between D-dimer and pediatric critical illness score.(2) It was longer of blood coagulation of prothrombin time,activated partial thromboplastin time,thrombin time and lower of fibrinogen,platelet counts in sepsis group.They were irrelative with pediatric critical illness score and prognosis.Conclusion The plasma D-dimer has certain value in the diagnosis of sepsis in fibrinolytic state.It can provide a theoretical basis by monitoring coagulation and fibrinolysis changes of sepsis in children for the early treatment and prognosis.