2012•Tianran chanwu yanjiu yu kaifaRequires access

Cytotoxic Constituents from Selaginella tamariscina

Wang Qiang

Abstract

Three selaginellins and seven biflavones were isolated from the whole plant of Selaginella tamariscina.Their structures were identified as selaginellin(1),selaginellin A(2),selaginellin B(3),amentoflavone(4),sequoiaflavone(5), bilobetin(6),ginkgetin(7),isoginkgetin(8),hinokiflavone(9),and isocryptomerin(10).Among them,compounds 1,5,and 8 were isolated from this plant for the first time.Additionally,selected compounds were evaluated for their cytotoxic activity against tested human cell lines,and compounds 1,4,7,8 and 9 showed selective cytotoxic activity.

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Key concepts: Amentoflavone, Selaginella, Cytotoxic T cell, Chemistry, Traditional medicine, Biflavonoids, Biology, Stereochemistry