Study on Effects of Combination Detection Some Extra Cellular Matrixes in Diagnosis of Liver Fibrosis

Objective To build diagnosis of liver fibrosis formula by combination detection some extra cellular matrixes.Methods Liver biopsy were used to gold standard of diagnosis liver fibrosis,serum fibrosis markers of liver fibrosis group and normal control group were detected.There are differentiate parameters between two groups in single factors analysis were used to for evaluated by logistic regression analysis,and building logistic regression equation.Results There was no difference between liver cirrhosis and severe chronic B liver disease(P0.05),but there was a significant difference among severe and middle chronic B liver disease and normal control group.The regression equation of some parameters was established,the sensitive and specification of regression evaluation diagnosis liver fibrosis were 86.7% and 80.0% respectively.Conclusion The combination of noninvasive parameters is more valuable than single parameter in the diagnosis of liver fibrosis,and having build regression evaluation by detect extra cellular matrixes can be progress liver fibrosis.