2007•Bulletin of Chinese CancerRequires access

The Expression of Cyclooxygenase-2 and VEGF in Breast Cancer and Its Significance

Feilin Cao

Abstract

[Purpose] To investigate the expression of cyclooxygenase-2(COX-2),vascular endothelial growth factor(VEGF)in breast cancer and its clinical significance.[Methods] The expression of COX-2 and VEGF in 96 cases of breast cancer tissues and cancer adjacent tissues were detected by reverse transcription-PCR.[Results] Expression of COX-2 mRNA and VEGF mRNA was 87.50% and 83.33% in breast cancer tissues;16.67% and 31.25% in cancer adjacent tissues respectively.The expression of COX-2 mRNA and VEGF mRNA was significantly different between cancer tissue and cancers adjacent tissue.[Conclusion] Expression of COX-2 and VEGF mRNA in breast cancer is significantly increased.Expression of COX-2 is closely correlated with expression of VEGF.

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Key concepts: Breast cancer, Messenger RNA, VEGF receptors, Cyclooxygenase, Vascular endothelial growth factor, Cancer, Medicine, Cancer research