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2007•Modern Medical JournalRequires access

Study of immunophenotype in chronic lymphocytic leukemia

Hui Yang

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Abstract

Objective To investigate the characteristics of immunophenotype of B chronic lymphocytic leukemia(B-CLL) and to evaluate the value of ZAP-70 and CD38 in diagnosis and prognosis of B-CLL.Methods The expression of CD5,CD10,CD19,CD20,CD22,CD23,FMC7,CD38 and ZAP-70 of 45 B-CLL patients were determined by four-color flow cytometry(FCM).Results Forty-five B-CLL patients were all over-expression of CD19 and CD20,among them,CD5,CD23,CD22 were expressed in 43,42,30 patients respectively,no case was seen expression of FMC7 and CD10.All the cases were divided into two groups,84.4%(38/45) was in ZAP-70+CD38+ /ZAP-70-CD38-group,15.6%(7/45) was in ZAP-70+CD38-/ZAP-70-CD38+ group.There was significant difference between the ratio of the two groups(P0.05).Conclusion The expression of CD5,CD23,CD19 simultaneously is the characteristics of immunophenotype of B-CLL.CD5 is existed in non-typical B-CLL.ZAP-70 and CD38 are concordantly expressed in B-CLL.

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What this paper is about

Objective To investigate the characteristics of immunophenotype of B chronic lymphocytic leukemia(B-CLL) and to evaluate the value of ZAP-70 and CD38 in diagnosis and prognosis of B-CLL.Methods The expression of CD5,CD10,CD19,CD20,CD22,CD23,FMC7,CD38 and ZAP-70 of 45 B-CLL patients were determined by four-color flow cytometry(FCM).Results Forty-five B-CLL patients were all over-expression of CD19 and CD20,among them,CD5,CD23,CD22 were expressed in 43,42,30 patients respectively,no case was seen expression of FMC7 and CD10.All the cases were divided into two groups,84.4%(38/45) was in ZAP-70+CD38+ /ZAP-70-CD38-group,15.6%(7/45) was in ZAP-70+CD38-/ZAP-70-CD38+ group.There was significant difference between the ratio of the two groups(P0.05).Conclusion The expression of CD5,CD23,CD19 simultaneously is the characteristics of immunophenotype of B-CLL.CD5 is existed in non-typical B-CLL.ZAP-70 and CD38 are concordantly expressed in B-CLL.

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Available abstract

Objective To investigate the characteristics of immunophenotype of B chronic lymphocytic leukemia(B-CLL) and to evaluate the value of ZAP-70 and CD38 in diagnosis and prognosis of B-CLL.Methods The expression of CD5,CD10,CD19,CD20,CD22,CD23,FMC7,CD38 and ZAP-70 of 45 B-CLL patients were determined by four-color flow cytometry(FCM).Results Forty-five B-CLL patients were all over-expression of CD19 and CD20,among them,CD5,CD23,CD22 were expressed in 43,42,30 patients respectively,no case was seen expression of FMC7 and CD10.All the cases were divided into two groups,84.4%(38/45) was in ZAP-70+CD38+ /ZAP-70-CD38-group,15.6%(7/45) was in ZAP-70+CD38-/ZAP-70-CD38+ group.There was significant difference between the ratio of the two groups(P0.05).Conclusion The expression of CD5,CD23,CD19 simultaneously is the characteristics of immunophenotype of B-CLL.CD5 is existed in non-typical B-CLL.ZAP-70 and CD38 are concordantly expressed in B-CLL.

Key concepts: Immunophenotyping, CD5, CD23, CD38, Chronic lymphocytic leukemia, CD20, Medicine, CD19

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