Malignant rhabdoid tumor of childhood:clinical and histopathological studies of 33 cases

Objective To study the clinicopathologic characteristics,immunohistochemistry,diagnosis and differential diagnosis of malignant rhabdoid tumor(MRT) of childhood.Methods The clinical data,histopathologic pections and immunohistochemistry of 33 MRT cases were reviewed.Results There were 14 MRT cases in kidney,11 cases in soft tissue,and 8 cases in central nervous system.The most cases were infancy and early childhood.The tumor size was usually large.Histological characteristics were rhabdoid cells and cytoplasmic inclusions.Immunohistochemically,CK,EMA and vimentin were positive;INI 1 was negative.Conclusion The histological features are rhabdoid cells,and the tumor cells express CK,EMA,and vimentin,but INI 1 is negative,which are the key to diagnosis and differential diagnosis.MRT is a highly malignant childhood neoplasm.The treatment is surgical resection followed by chemotherapy and radiation.