2011•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access
Expression of CD44v6 and Smad7 in ovarian endometriosis and its significance
Xiaoling Fang
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Abstract
Objective To investigate the expression CD44v6 and Smad7 in endometriosis and the role of CD44v6 and Smad7 in the pathogenesis of endometriosis.Methods The expressions of CD44v6 and Smad7 were detected with immunohistochemiscal technic in 30 cases of ovarian endometriotic tissues and 25 cases eutopic endometrium tissues with endometriosis and 30 cases of normal endometriums without endometriosis.Results The CD44v6 expression of ectopic endometrium group was higher than that of eutopic endometrium group and the control group(P 0.05),we also found CD44v6 in eutopic endometrium group and the control group of the secretory phase endometrium tissues,respectively,higher than the proliferative phase with the group(P 0.05).The Smad7 expression of ectopic endometrium and eutopic endometrium group were lower than that of the control group(P 0.05),No difference in Smad7 expression was shown between the proliferative phase endometrium and the secretory phase endometrium of eutopic endometrium group and control group(P 0.05).The expression of CD44v6 had no correlation with that of Smad7 in each group endometrium(P 0.05).Conclusion The up regulation of CD44v6 and the low regulation of Smad7 in endometriosis suggest that CD44v6 and Smad7 may play a role in the pathogenesis of endometriosis.