1999•Medical Journal of National Defending Forces in North ChinaRequires access
Expression of the CD15 antigen in thyroid neoplasms and its significance
Pla Zhangjiakou
Open publisher page 0 citations
Abstract
Objective To study the expression of CD15 antigen in thyroid cancer and its significance. Methods The expression of CD15 antigen in 50 thyroid cancers, 20 adjacent noncancerous portion, 45 adenoma and 10 normal thyroid tissue were respectively investigated by Microwave-LSAB im-munohistochemical technique. Results The expression rate of CD15 in thyroid cancer was 68.0%, which was significantly higher than 35.0% in adjacent noncancerous portion and 42.0% in adenoma (P0. 05). CD15 immunoreactivity was weakly presented in 2 of 10 normal tissue. No correlation was observed between expression of CD15 and histological grading of thyroid cancer. The expression of CD15 in lymph node positive and grade Ⅲ-Ⅳ were both higher than that in negative cases and grade Ⅰ-Ⅱ (P0.05). The percentage of recurrence and death in CD15 positive cases were notably higher than that in negative cases ( P 0.05). Conclusion The expression of CD15 can be regarded as a parameter for evaluating the degree of malignacy, biological behavior and prognosis of thyroid cancer.