Relationship among serum uric acid,urinary albumin excretion rate and brachial arterial flow mediated vasodilatation function in patients with type 2 diabetes mellitus

Objective To investigate the relationship among serum uric acid(UA),urinary microalbumin(MA) and brachial arterial flow mediated vasodilatation(FMD) function in patients with type 2 diabetes mellitus.Methods One hundred and four type 2 diabetic patients were divided into two groups according to the UAER,group A with UAER between 20 and 200μg/min(n = 63) and group B with UAER200μg/min(n =41);the patients were also classified into hyperuricemia group(group C,n=64) and normal blood UA group(group D,n = 40).The disease course,UA,fasting blood glucose (FBG),HbA_(1c),triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL-C),high density lipoproteins(HDLC), UAER and FMD were determined and compared among these groups.The relationship of UAER and hyperuricemia with FMD was analyzed.Results The disease course,UA,FBG and UAER levels in groups A and C were significantly higher than those in groups B and D(all P0.05),while FMD was decreased(P0.05).The brachial arterial FMD was independently correlated to the disease course,UA and UAER(r=-0.305,-0.314,-0.285,respectively,all P0.05),and a significant positive correlation was noted between UA and UAER(r =0.241,P0.05).Conclusion Endothelial dysfunction in type 2 diabetic patients was significantly correlated to the disease course,UA and UAER levels,which was helpful to evaluate and predict endothelial dysfunction in type 2 diabetic patients.