Effects of propofol on lung injury induced by renal ischemia-reperfusion in rats

Objective To study the effects of propofol on lung injury induced by renal ischemia-reperfusion in rats. Methods Total 48 Wistar rats were randomly divided into 6 groups, including Group C (sham-operated animals), Group R (renal ischemia-reperfusion), Group P1 (administration of propofol at 1 hour before ischemia), Group P2 (at the moment of ischemia), Group P3 (at the moment of reperfusion), Group P4 (at 1 hour after reperfusion). At the end of the reperfusion period, blood samples and lung tissues were collected. SOD activity, MDA concentration and morphologic changes of the lungs were examined. Results Compared with Group C, SOD activity decreased significantly and MDA concentration increased significantly in Group R(P 0.01). Light microscopic findings show the pulmonary structure was badly injuried in group R. Compared with Group R, the injured severity was obviously relieved in the groups which received propofol excluding Group P4. The changes were different in the groups which received propofol. Conclusions Renal ischemia-reperfusion can lead to injury of lung. Poropofol can effectively protect pulmonary injury induced by renal ischemia-reperfusion. Different time in which propofol was administrated can influent on the protection of propofol.