Vinorelbine plus oxaliplatin in the treatment of 26 cases of advanced non-small cell lung cancer

Objective To evaluate the efficacy and safety of vinorelbine plus oxaliplatin in treatment of advanced non-small cell lung cancer (NSCLC) .Methods Twenty-six patients with NSCLC entered the study.The chemotherapy regimen consisted of vinorelbine 25 mg/m2 iv injection on days 1 and 8, oxaliplatin 130 mg/m2 iv infusion for 4 hours on day 1, repeated every 21-28 days. Results There were 9 partial response, 12 stable disease and 5 progression of disease, with the response rate being 34.6% . The major adverse effects were myelosuppression grade 3-4 occurring in 11 patients (42.3 % ) , neuro- sensory toxicity and vomiting observed in 80.8 % and 42.3 % of the patients respectively. Conclusions The vinorelbine plus oxaliplatin combined chemotherapy is an effective regimen for advanced non-small cell lung cancer with tolerable toxicity and deserves further evaluation.