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Curative effect of malignant melanoma treated by interferon alpha combined chemotherapy

Xie Yue-yun

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Abstract

Objective:To study the therapeutic effect of interferon-α condined with chemotherapy for malignant melanoma.Methods: Twenty five advanced malignant melanoma patients was treatid by interferon alpha combined with chemotherapy that was consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program) as curative group,25 advanced melanoma was treated with chemotherapy that was consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program)as compared group.Results: The response rates to chemotherapy in curative and compared groups were 64% and 36% respectively(P0.05),immune level of patients treated with interferon alpha combined with chemotherapy continued to invrease,inversely,immune level of patients treated with pure chemotherapy decreased obviously,the difference was significant.The survival time was significant different between curative group and compared group.Conclusion: Interferon alpha combined with chemotherapy consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program)can obtain satisfied therapeutic effect.

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Objective:To study the therapeutic effect of interferon-α condined with chemotherapy for malignant melanoma.Methods: Twenty five advanced malignant melanoma patients was treatid by interferon alpha combined with chemotherapy that was consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program) as curative group,25 advanced melanoma was treated with chemotherapy that was consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program)as compared group.Results: The response rates to chemotherapy in curative and compared groups were 64% and 36% respectively(P0.05),immune level of patients treated with interferon alpha combined with chemotherapy continued to invrease,inversely,immune level of patients treated with pure chemotherapy decreased obviously,the difference was significant.The survival time was significant different between curative group and compared group.Conclusion: Interferon alpha combined with chemotherapy consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program)can obtain satisfied therapeutic effect.

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Available abstract

Objective:To study the therapeutic effect of interferon-α condined with chemotherapy for malignant melanoma.Methods: Twenty five advanced malignant melanoma patients was treatid by interferon alpha combined with chemotherapy that was consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program) as curative group,25 advanced melanoma was treated with chemotherapy that was consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program)as compared group.Results: The response rates to chemotherapy in curative and compared groups were 64% and 36% respectively(P0.05),immune level of patients treated with interferon alpha combined with chemotherapy continued to invrease,inversely,immune level of patients treated with pure chemotherapy decreased obviously,the difference was significant.The survival time was significant different between curative group and compared group.Conclusion: Interferon alpha combined with chemotherapy consisted of dacarbazine(DTIC),chlorethyl(CCNU),adriamycin(ADM)or pharmorubicin(EPI),vinblastine(VCR),cisplatin(DDP)(DDVAC program)can obtain satisfied therapeutic effect.

Key concepts: Dacarbazine, Vinblastine, Chemotherapy, Melanoma, Medicine, Cisplatin, Alpha interferon, Internal medicine

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Curative effect of malignant melanoma treated by interferon alpha combined chemotherapy — Research Paper | ScholarLens