Progressive cerebral infarction risk factors and serum proinflammatory cytokine level research

Objective To investigate the risk factors and serum IL-1β, IL-6 level in progressive cerebral infarction patients.Methods Eighty patients with acute cerebral infarction,including non-progressive cerebral infarction(n=33,non-progressive group) and patients with progressive cerebral infarction(n=47,progressive group).The other 40 patients who came to our physical examination center were selected as a control group.We detected the group of patients with biochemical indicators,Elisa assay of serum IL-1β,IL-6 levels.Results In the progressive group,the level of GLU,FIB,Hcy was significantly higher than the non-progressive group.Serum IL-1β,IL-6 levels in the progressive group were significantly higher than those in the non-progressive group.Advanced levels of serum IL-1β,IL-6 levels were significantly higher than in the non-progressive group.The early CT abnormalities and the incidence of massive cerebral infarction in the progressive group were significantly higher than those in the non-progressive group.Conclusion Hyperglycemia hyperfibrinogenemia and high hyperhomocysteinemia as risk factors for progressive cerebral infarction,serum IL-1β,and IL-6 levels have early warning significance for progressive cerebral infarction.