Study on serum variation of Liver cirrhosis patients with spontaneous peritonitis and cytokines in ascites

Objective: To study on serum variation of Liver cirrhosis patients with spontaneous peritonitis and cytokines in ascites caused by Gram-positive bacteria or by Gram-negative bacteria, so as to insturct clinical use of antibiotics.Methods: Ascites of the patients with liver cirrhosis were carried out routine test to distinguish between exudative ascites and transudate ascites. All patients with exudative ascites had bacteria cultured and drug-effective tested in their ascites. At the same time, Nitric oxide(NO), Tumor Necrosis Factor-a(TNFa), LPS were tested in the serum and ascites of all patients with liver cirrhosis ascites.Results: NO, TNFa, LPS levels in the serum and ascites of the exudative ascites patients with liver cirrhosis were obviously higher than those in the serum and ascites of transudate ascites patients with liver cirrhosis. NO, TNFa, LPS levels in ascites infected by Gram-positive bacteria were obviously higher than those by Gram-negative bacteria. Conclusion: Test of NO, TNFa, LPS in the serum and ascites of the patients with liver cirrhosis ascites can contribute to distinguishing between exudative ascites and transudate ascites, and distinguishing between spontaneity peritonitis infected by Gram-positive bacteria and by Gram-negative bacteria so as to instruct clinical use of drugs.