Progress of research on genetic polymorphism of CYP450s

In recent years,correlation between genotype and phenotype of CYP450s is gradually paid attention.In the region of clinical rational use of drugs,we hope to know everyone's activity of CYP450s respectively by genotype analysis.Then we can not only improve therapeutical effect of drugs but also reduce their adverse reactions.In the region of new drug research and development,study of function of CYP450s can guide design,screening and optimization of new drugs.This paper summarized research development of genetic polymorphism of CYP450s in recent years,and introduced six main drug-metabolizing enzymes respectively;they are CYP2C19,CYP2C9,CYP3A4,CYP2D6,CYP1A2 and CYP2E1.Research on genetic polymorphism of CYP450s is significant to drug design,screening,evaluation and optimization.