Detection of insulin resistance and plasma high sensitive C-reactive protein of coronary heart disease patient

Aim:To explore the correlation between plasma high sensitive C-reactive protein(hs-CRP),insulin resistance(IR)and the severity of coronary artery lesion of coronary heart disease(CHD).Methods:A total of 88 in-patients who received coronary angiography were allocated into 4 groups:normal control group(n=15),stable angina pectoris(SAP)group(n=31),unstable angina pectoris(UAP)group(n=23),acute myocardial infarction(AMI)group(n=19).The plasma hs-CRP level was measured with immune-reinforced turbidimetry methods.The concentration of serum insulin was measured using ELISA,IRI was calculated by HOMA model.Gensini score was measured according to the severity of coronary artery lesions.Results:The plasma hs-CRP level and IRI of CHD patients were significantly higher than those of the normal control group(P0.05).Among CHD groups,the plasma hs-CRP level and IRI in AMI group and UAP group were significantly higher than those in SAP group(P0.05).Pearson relation analysis showed that:Gensini score was positively related with IRI hs-CRP,IRI was positively related with hs-CRP(r were 0.921,0.669 and 0.619,respectively,P0.05).Conclusion:IR and hs-CRP were both related with the instability of plaques.IR and hs-CRP affect and promote each other and play an important role in the development of CHD.