Expressions of LOX and HIF-1 protein in breast cancer tissues and their clinical significance

OBJECTIVE:To study the expression of LOX and HIF-1 protein in human breast cancer tissues and explore the relationship between LOX expression and patient's age,tumor size,axillary node metastasis,clinical stage,HIF-1 protein expression.METHODS:The expressions of LOX and HIF-1 Protein in 56 cases of human breast cancer tissues,56 normal breast tissues and 20 cases of breast benign lesion tissues was detected by SP immunohistochemistry.RESULTS:The expression rate of LOX protein in breast cancer,normal breast tissues and breast benign lesion tissue were 48.21%(27/56),26.78%(15/56) and 20.00%(4/20),statistical difference was found among them(P=0.019).Statistical difference was found between breast carcinoma group,and benign lesion group(P=0.028).And no significant difference was found between normal breast tissues and benign lesion(P=0.519).The expression of LOX protein were associated with clinical stage(P=0.005),lymph node metastasis(P=0.042),but had no correlation with age and tumor size(P=0.182 and 0.058).The LOX protein had significant positive correlation with the HIF-1α protein expression in breast cancer(r=0.368,P=0.005).CONCLUSIONS:LOX protein expression is increased in breast cancer tumor tissues.LOX is related with clinical stage and lymph node metastasis.LOX and HIF-1α have a synergistic effect in breast cancer invasion and metastasis.