High-Throughput Genome of Caenorhabditis Elegans

Caenorhabditis elegans serves as a good model organism for the study of cell biology,and the phenomenon of RNA-mediated interference(RNAi) was first discovered in the nematode Caenorhabditis elegans.RNA interference can target gene specifically,and it is simple,easy to perform.A high-throughput,genome-wide function analysis has been developed on the basis of RNAi technique.Several research teams used large-scale RNAi to systematically examine various C.elegans gene for knock-down phenotypes.The specific RNAi method and functional genomic analyses by high-throughput RNAi have provided new insights in a wide variety of biological processes in C.elegans.