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2003•Zhongguo kangganran hualiao zazhiRequires access

In vitro antibacterial activity of oxacephems to clinical isolates producing extended-spectrum β-lactamases

Qing Yang

Open publisher page 2 citations

Abstract

Objective: To investigate the in vitro activity of oxacephems against extended spectrum β lactamases(ESBLs) producing strains. Methods:A total of 98 of Escherichia coli and Klebsiella pneumoniae ESBLs producing strains were collected from Beijing and Hangzhou hospitals, and the genotypes of ESBLs were detected. The minimum inhibitory concentrations(MIC) of moxalactam, flomoxef on these strains were determined by agar dilution method, and the MICs of the other antibiotics were determined by E test method. Results:Imipenem is still the most active agent (100%) against ESBLs producing strains, followed by moxalactam(99.0%), flomoxef(98.0%) and ceftazidime(74.5%). Conclusions:Oxacephems had good in vitro activity against ESBLs producing strains.

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What this paper is about

Objective: To investigate the in vitro activity of oxacephems against extended spectrum β lactamases(ESBLs) producing strains. Methods:A total of 98 of Escherichia coli and Klebsiella pneumoniae ESBLs producing strains were collected from Beijing and Hangzhou hospitals, and the genotypes of ESBLs were detected. The minimum inhibitory concentrations(MIC) of moxalactam, flomoxef on these strains were determined by agar dilution method, and the MICs of the other antibiotics were determined by E test method. Results:Imipenem is still the most active agent (100%) against ESBLs producing strains, followed by moxalactam(99.0%), flomoxef(98.0%) and ceftazidime(74.5%). Conclusions:Oxacephems had good in vitro activity against ESBLs producing strains.

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Available abstract

Objective: To investigate the in vitro activity of oxacephems against extended spectrum β lactamases(ESBLs) producing strains. Methods:A total of 98 of Escherichia coli and Klebsiella pneumoniae ESBLs producing strains were collected from Beijing and Hangzhou hospitals, and the genotypes of ESBLs were detected. The minimum inhibitory concentrations(MIC) of moxalactam, flomoxef on these strains were determined by agar dilution method, and the MICs of the other antibiotics were determined by E test method. Results:Imipenem is still the most active agent (100%) against ESBLs producing strains, followed by moxalactam(99.0%), flomoxef(98.0%) and ceftazidime(74.5%). Conclusions:Oxacephems had good in vitro activity against ESBLs producing strains.

Key concepts: Moxalactam, Imipenem, Klebsiella pneumoniae, Ceftazidime, Agar dilution, Microbiology, Agar Dilution Method, Minimum inhibitory concentration

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