The study of the dynamic changes of creatine kinase and its isoenzyme in neonates with hypoxic-ischemia encephalopathy

Objective To explore the dynamic changes of creatine kinase,brain specific isoenzyme(CK-BB)and MB isoenzyme of creatine kinase(CK-MB)in neonates with hypoxic ischemic encephalopathy(HIE)and further explore the clinical sense.Methods Thirty-two neonates with HIE were treated in Yantai Mountain Hospital from May 2004 to January 2005,and 30 normal neonates were involved in the study.The HIE group and the control group were drawn blood 24 hours after birth,on the third day and the seventh day.The serum level of CK、CK-MB and CK-BB was measured.Results(1)The serum levels of CK,CK-MB and CK-BB in infants with HIE were higher than that in control(P0.05),and became higher and higher with the worsening condition of HIE.They all peaked within 24 hours after birth,then began to decrease gradually from the third day.The serum CK,CK-MB and CK-BB levels of moderate HIE reduced to normal on the seventh day.Severe HIE derecreased obviously at the seventh day but was still significantly higher than that in control(P0.01).(2)There was significant difference of serum CK,CK-MB levels between moderate,severe HIE and control,mild HIE.There was no significant difference between mild HIE and control group about the serum CK,CK-MB levels.The serum CK-BB levels of mild,moderate and severe HIE were all positively higher than that of control group(P0.01).Conclusion The present data suggests that the changes of serum CK,CK-MB and CK-BB levels are related to severity of HIE.They are the early distinctive and specific markers of brain-heart damage.The dynamic changes of serum CK,CK-MB and CK-BB levels are of great value in assessing prognosis,early diagnosis,determining the degree and performing treatment for HIE.