Role of Histamine H4 Receptor in Allergic Inflammation

Histamine is a key chemical mediator in allergic inflammatory responses.The allergic inflammatory responses resulting from the release of histamine have been thought to be mediated only by the histamine H1 receptor.However,the discovery of a fourth histamine receptor and its expression on numerous immune organ and cells has induced a re-evaluation of the actions of histamine.The histamine H4R is involved widely in allergic inflammation and shown a important function in those immune responses. Histamine H4R selective antagonists have extremly high affinity to H4R and also demonstrate efficacy as anfi-inflammtory agents and immune modulator.The H4R antagonists appear to be a novel and potential therapy for a variety of allergic diseases.