2013•Chinese Journal of Health Laboratory TechnologyRequires access
Clinical value of serum and urine κ /λ light chain in diagnosis of multiple myeloma
Yang Xiao-ya
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Abstract
Objective To investigate the clinical value of serum and urine κ /λ light chain in diagnosis of multiple myeloma( MM). Methods A total of 66 MM patients and 30 healthy controls were enrolled in this study. The levels of serum and urine κ/λ light chain were measured by rate nephelometry. The sensitivity and specificity of κ/λ light chain for detecting MM were evaluated. Results The levels of serum and urine κ / λ light chain were higher in 66 MM patients compared to healthy controls( P 0. 05). And more significant differences were found between the male patients above 40 years old and healthy controls( P 0. 01). Conclusion The combined determination of serum and urine κ/λ light chain shows high sensitivity and specificity in the diagnosis of multiple myeloma( MM). The method was convenient,rapid and without hurt. So it is helpful to early prevent the multiple myeloma promptly,especially in the male patients above 40 years old.