2008•Zhonghua zhongyiyao zazhiRequires access

Effect of FeixianFang on MMP-1,MMP-2 and TIMP-1,TIMP-2 in rats model of pulmonary fibrosis induced by bleocin

Jiang Liang-duo

Abstract

Objective: To observe the effect of FeixianFang on matrix rebuilding of pulmonary fibrosis in rats.Methods: Rats were randomly divided into the model group,the sham operation group,the FeixianFang group and the prednisone group.Pulmonary fibrosis model was set up by intratracheal injection of bleocin.On the 14th,28th and 45th day,MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum were detected.Results: FeixianFang can significantly reduce the level of MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum of rats with pulmonary fibrosis.Conculusion: FeixianFang can inhibit matrix rebuilding in pulmonary fibrosis rats.

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Key concepts: Matrix metalloproteinase, Pulmonary fibrosis, Medicine, Prednisone, Fibrosis, Internal medicine, Pathology, Pharmacology