Analysis on 110 cases of COPD with acute respiratory failure treated by non-invasive ventilation

Objective To study the clinical use of non-invasive ventilation on the patients with acute exacerbation of COPD(COPD-AE).Method 110 cases of COPD with acute respiratory failure were chosen and divided into three groups according to the blood gas analysis when inclusion.Tha patients were divided group A,group B and group C according to the patient's blood gas.The patients were treated with non-invasive ventilation based on the conventional therapy.We observed the blood gas analysis, oxygenation index before mechanical ventilation and 1,24,72 hours after mechanical ventilation,the setting of ventilators,and the duration of mechanical ventilation.Results The total effective power were 98%.The improvement of the blood gas analysis and the oxygenation index before and after treatment was significant.The PaCO2 of group B and group C was significantly higher than that of group A 72 hours after mechanical ventilation(P0.01).But the pH and the oxygenation were not significant different among three groups 72 hours after mechanical ventilation (P0.05).The EPAP of three groups were 4 cmH2O.The IPAP of group B was significantly higher than that of group A (P0.01).The IPAP of group C was significantly higher than that of group A and group B(P0.01).The duration of mechanical ventilation everyday and the total duration of mechanical ventilation in group B were significantly longer than those in group A(P0.01),and those in group C was significantly longer than those in group A and group B.The patients except two of group C were cured and discharged.Conclusion The significant effect can be gotten with non-invasive mechanical ventilation on the patients of COPD-AE.The different setting of ventilator should be used in the patients suffering from the different degree of COPD-AE.