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2013•Journal of International Obstetrics and GynecologyRequires access

Expression and Clinical Significance of MicroRNA-210 in Ovarian Cancer

Bao Liu-pin

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Abstract

Objective:Detection the expression of miR-210 and investigation its roles in epithelial ovarian cancer(EOC).Methods:Poly(A)-RT-qPCR was used to detect the expression of miR-210 in epithelial ovarian cancers and benign epithelial ovarian cysts and normal ovarian tissues.Results:miR-210 in ovarian cancer group was lower than that of benign ovarian tumors and normal ovarian group,significant difference among the three groups(F=893.213,P=0.000).With the progress of the clinical staging of ovarian cancer tissues and tissue differentiation,miR-210 expression there has a downward trend.Conclusions:Our data suggest that miR-210 expressed lowerly in EOC,it might play an important role as an anti-oncogene in the genesis and development of epithelial ovarian cancer.It is bound with lymphatic metastasis,stages of ovarian cancer and tissus grading.

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Objective:Detection the expression of miR-210 and investigation its roles in epithelial ovarian cancer(EOC).Methods:Poly(A)-RT-qPCR was used to detect the expression of miR-210 in epithelial ovarian cancers and benign epithelial ovarian cysts and normal ovarian tissues.Results:miR-210 in ovarian cancer group was lower than that of benign ovarian tumors and normal ovarian group,significant difference among the three groups(F=893.213,P=0.000).With the progress of the clinical staging of ovarian cancer tissues and tissue differentiation,miR-210 expression there has a downward trend.Conclusions:Our data suggest that miR-210 expressed lowerly in EOC,it might play an important role as an anti-oncogene in the genesis and development of epithelial ovarian cancer.It is bound with lymphatic metastasis,stages of ovarian cancer and tissus grading.

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Available abstract

Objective:Detection the expression of miR-210 and investigation its roles in epithelial ovarian cancer(EOC).Methods:Poly(A)-RT-qPCR was used to detect the expression of miR-210 in epithelial ovarian cancers and benign epithelial ovarian cysts and normal ovarian tissues.Results:miR-210 in ovarian cancer group was lower than that of benign ovarian tumors and normal ovarian group,significant difference among the three groups(F=893.213,P=0.000).With the progress of the clinical staging of ovarian cancer tissues and tissue differentiation,miR-210 expression there has a downward trend.Conclusions:Our data suggest that miR-210 expressed lowerly in EOC,it might play an important role as an anti-oncogene in the genesis and development of epithelial ovarian cancer.It is bound with lymphatic metastasis,stages of ovarian cancer and tissus grading.

Key concepts: Ovarian cancer, microRNA, Grading (engineering), Oncogene, Epithelial ovarian cancer, Metastasis, Clinical significance, Pathology

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