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2007•Jiangsu Medical JournalRequires access

The expression of γ-aminobutyric acid transporters-1 in the spinal cord and dorsal root ganglion neurons in rats with chronic constriction injury of sciatic nerve

Zhou Jiongwei

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Abstract

Objective To investigate the expression of γ-aminobutyric acid transporters-1(GAT-1) in the spinal cord and dorsal root ganglion(DRG) neurons in rats with chronic sciatic nerve injury(CCI).Methods Immunocytochemistry was employed to investigate the GAT-1 expression in L_ 4-5 DRG neurons in CCI rats on the 3rd,7th,14th,and 28th day of nerve injury,which was compared with that in naive and sham operative rats.Results There was a significant increase in the numbers and grey level of GAT-1 immunoreactive cells in CCI 3d,7d,14d and 28d groups compared with those in naive or sham operation groups(P0.05 or P0.01).Conclusion The expression of GAT-1 is increased after CCI,which may play a role in the pathologic process of chronic nerve pain.

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Objective To investigate the expression of γ-aminobutyric acid transporters-1(GAT-1) in the spinal cord and dorsal root ganglion(DRG) neurons in rats with chronic sciatic nerve injury(CCI).Methods Immunocytochemistry was employed to investigate the GAT-1 expression in L_ 4-5 DRG neurons in CCI rats on the 3rd,7th,14th,and 28th day of nerve injury,which was compared with that in naive and sham operative rats.Results There was a significant increase in the numbers and grey level of GAT-1 immunoreactive cells in CCI 3d,7d,14d and 28d groups compared with those in naive or sham operation groups(P0.05 or P0.01).Conclusion The expression of GAT-1 is increased after CCI,which may play a role in the pathologic process of chronic nerve pain.

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Available abstract

Objective To investigate the expression of γ-aminobutyric acid transporters-1(GAT-1) in the spinal cord and dorsal root ganglion(DRG) neurons in rats with chronic sciatic nerve injury(CCI).Methods Immunocytochemistry was employed to investigate the GAT-1 expression in L_ 4-5 DRG neurons in CCI rats on the 3rd,7th,14th,and 28th day of nerve injury,which was compared with that in naive and sham operative rats.Results There was a significant increase in the numbers and grey level of GAT-1 immunoreactive cells in CCI 3d,7d,14d and 28d groups compared with those in naive or sham operation groups(P0.05 or P0.01).Conclusion The expression of GAT-1 is increased after CCI,which may play a role in the pathologic process of chronic nerve pain.

Key concepts: Dorsal root ganglion, Spinal cord, Immunocytochemistry, Sciatic nerve, Medicine, Sciatic nerve injury, Neuropathic pain, Anesthesia

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The expression of γ-aminobutyric acid transporters-1 in the spinal cord and dorsal root ganglion neurons in rats with chronic constriction injury of sciatic nerve — Research Paper | ScholarLens