2014•Journal of clinical and experimental medicineRequires access
The curative observation of cyclosporine combined with danazol in the treatment of refractory idiopathic thrombocytopenic purpura
Liu Chuan-ca
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Abstract
Objective To investigate the clinical effect of cyclosporine A( CSA) combined with danazol in the treatment of refractory idiopathic thrombocytopenic purpura( ITP). Methods 45 patients with refractory ITP were randomly divided into two groups,the control group( n = 21 cases) was treated with vincristine and cyclophosphamide,and the observation group( n = 24 cases) was treated with CSA combined with danazol. Two groups were treated for 3 months. The clinical effect and the rate of adverse reaction of two groups were compared. Results The total efficiency of the observation group( 79. 2%) was significantly higher than that of the control group( 66. 7%)( P 0. 05); and there was no significant difference between the rate of adverse reaction in two groups during the treatment( 45. 8%,47. 6%)( P 0. 05). Conclusion The treatment of CSA combined with danazol for refractory ITP had a significantly effect,safe and reliable. It was worthy of clinical application.