Clinical distribution and drug resistance Analysis of Escherichia coli

Objective To investigate the clinical distribution and drug resistance of Escherichia coli, providing evidences for the clinical usage of antibacterial agents. Methods API identification cards (France’s BioMerieux) are used to identified bacterial strains. ATB is used for drug sensitivity test. Enhancing Kirby-Bauer method with enzyme-inhibitor is used to corroborate the ESBLs strains. All the results have been analyzed. Re-sults Among the 102 strains of E. coli,the isolation rate of urine is the highest(56 /102),then the next is the rate of sputum(34 /102),liquor puris(10 /102),bile and blood(1 /102). 36 strains of ESBL-producing E. coli are identified,with a positive rate of 35% . The resistance rates of ESBL-producing E. coli strains to meropenem and imipenem are 0,ciprofloxacin is 94% ,cefepime is 76% ,SMZ-TMP is 75% ,gentamicin 67% ,nebcin 64% , netilmicin 61% ,amikacin 28% . And the resistance rates to all penicillins and cephalosporin I,II,III reach up 100% . The resistance rates of most of the ESBL-producing strains are higher than the non-ESBL-producing strains,the top three of which are amoxicillin(91% ),ticarcillin(88% ),cefalotin(82% ). Then the other antibi-otics (including cefoxitin,cefotaxime,netillmicin,amoxicillin + clavulanic acid,cefepime,piperacillin + tazobac-tam,ceftazidime,amikacin) have an average resistance rate which is less than 30% . Conclusion Given the in-consistency of the drug resistance between the ESBL-producing strains and the non-ones,it plays a very impor-tant role to identify the ESBL-producing strains for directing the clinical treatment. Clinicians should choose the sensitive antibiotics according to the drug sensitivity reports.