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2007•Journal of Practical Medical TechniquesRequires access

Studies on the Pharmacologic Mechanism of Resveratrol on Rats with Nasopharyngeal Carcinoma

Bo Ying Wu

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Abstract

Objective To investigate whether caspase-6 was activated during resveratrol-induced apoptosis of rats'nasopharyngeal carcinoma cells CNE-2Z.Methods The changes of caspase-6 mRNA was detected by semi-quantitative RT-PCR.The changes of caspase-6 activity was determined by colorimetric assay.Results After CNE-2Z cells were treated with 0 μmol/L,30 μmol/L,60 μmol/L,120 μmol/L,240 μmol/L resveratrol for 24 hours,respectively,the expression of caspsae-6 mRNA was increased in a concentration-dependent manner(P0.01).The caspase-6 activity was increased in a concentration and time-dependent manner(P0.01).Conclusion Caspase-6 is activated during resveratrol-induced apoptosis of CNE-2Z cells.

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What this paper is about

Objective To investigate whether caspase-6 was activated during resveratrol-induced apoptosis of rats'nasopharyngeal carcinoma cells CNE-2Z.Methods The changes of caspase-6 mRNA was detected by semi-quantitative RT-PCR.The changes of caspase-6 activity was determined by colorimetric assay.Results After CNE-2Z cells were treated with 0 μmol/L,30 μmol/L,60 μmol/L,120 μmol/L,240 μmol/L resveratrol for 24 hours,respectively,the expression of caspsae-6 mRNA was increased in a concentration-dependent manner(P0.01).The caspase-6 activity was increased in a concentration and time-dependent manner(P0.01).Conclusion Caspase-6 is activated during resveratrol-induced apoptosis of CNE-2Z cells.

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Available abstract

Objective To investigate whether caspase-6 was activated during resveratrol-induced apoptosis of rats'nasopharyngeal carcinoma cells CNE-2Z.Methods The changes of caspase-6 mRNA was detected by semi-quantitative RT-PCR.The changes of caspase-6 activity was determined by colorimetric assay.Results After CNE-2Z cells were treated with 0 μmol/L,30 μmol/L,60 μmol/L,120 μmol/L,240 μmol/L resveratrol for 24 hours,respectively,the expression of caspsae-6 mRNA was increased in a concentration-dependent manner(P0.01).The caspase-6 activity was increased in a concentration and time-dependent manner(P0.01).Conclusion Caspase-6 is activated during resveratrol-induced apoptosis of CNE-2Z cells.

Key concepts: Resveratrol, Nasopharyngeal carcinoma, Medicine, Apoptosis, Messenger RNA, Caspase 3, Molecular biology, Pharmacology

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