Distribution of Clinical Pathogens and Analysis of Drug Resistance in Our Hospital During 2010-2012

OBJECTIVE: To investigate the characteristics of the distribution of common clinical pathogens in our hospital during 2010-2012 and their resistance to commonly used antibiotics for reference of clinical rational use of antibiotics in our hospital. METHODS: The pathogens isolated from the specimens sent for bacterial culture during2010-2012 and their drug resistance were analyzed statistically. RESULTS: A total of 5 992 pathogen strains were isolated in our hospital during 2010-2012,of which,1 394( 23. 26%) were gram-positive strains and 4 691( 78. 29%) gram-negative strains. Among the gram-positive strains,Methicillin resistant S. aureus( MRSA) strains represented an average of 68. 37% of total Staphylococcus aureus strains,and methicillin-resistant Staphylococcus aureus( MRSA) strains accounted for an average of 68. 37% of total Staphylococcus aureus,and methicillin-resistant Staphylococcus epidermidis Staphylococcus epidermidis( MRSE) strains accounted for an average 69. 51% of total Staphylococcus epidermidis strains. Among the gram-negative strains,Escherichia coli( E. coli) were the most common strains in Enterobacteriaceae and Pseudomonas aeruginosa were more common among non-zymophytes. The detection rate of extended-spectrum beta-lactamases( ESBL) in Enterobacteriaceae E. coli was 64. 5%. The detection rate of Klebsiella pneumoniae was 47. 3%. CONCLUSION: Gram-negative bacilli took the lead in nosocomial infection,and the bacterial resistance showed a rising trend,thus it is important to take effective control measures to strengthen the monitoring of drug resistance,especially on the monitoring of enzyme-producing bacteria and multiresistant bacteria so as to provide reference for clinical proper use of antibiotics.