Eosinophilic and non-eosinophilic chronic rhinosinusitis and nasal polyps clinical comparative study

【Objective】To study the eosinophilic and non-eosinophilic chronic nasal sinusitis with nasal polyps' clinical characteristics.【Methods】Retrospective analysis of 76 cases with chronic sinusitis and nasal polyps,according to peripheral blood eosinophilia and nasal secretion smear eosinophil content,which can be divided into eosinophilic and non-eosinophilic group,compared two groups of symptoms of VAS score,nasal polyps,nasal sinus CT subjective scoring the score of Lund-MacKay,olfactory function,nasal resistance,total serum IgE index difference.【Results】in the 76 patients,non eosinophilic group 45 cases,31 cases of eosinophilic group.Non eosinophilic group of nasal polyps in clinical cases accounted for 59.2%;VAS score between two groups of symptoms of nasal polyps and subjective scores showed no significant difference(t = 0.87,P = 0.40;t = 0.58,P = 0.64).Sinus CT Lund-MacKay score,eosinophilic group ethmoid lesion degree is a severe eosinophilic group,there was significant difference(t = 2.11,P = 0.03),while the rest of the paranasal sinuses and OMC showed no significant difference.Two groups of olfactory function and bilateral nasal resistance and no significant difference(t = 0.15,P = 0.88;t = 0.57,P = 0.61).【Conclusions】Eosinophils rise in the pathogenesis of chronic sinusitis and nasal polyp did not leading role,the clinical symptoms,nasal polyp size,olfactory function and nasal resistance,etc,no significant effect,but may be and ethmoid sinus lesions has certain degree of correlation.