Analysis of clinical features and drugs resistance of 68 cases of lower respiratory tract infection caused by Escherichia coli from 10 hospitals in Tianjin

Objective:To investigate the clinical features and drug resistance of lower respiratory tract infecˉtion caused by Escherichia Coli from respiration department of10hospitals in Tianjin during2000～2002.Methods:The clinical data and antibiotic susceptibility studies of68cases were reviewed.Results:In the cases of lower respiratory tract infection caused by Escherichia Coli from respiration department,most cases which had underlying diseases were community-acquired pneumonia,and chronic bronchitis acute attack and nosocomal pulmonary infection were the next.Lower respiratory tract infection caused by Escherichia Coli ocˉcurred mostly in the older patiens,especially accompanied by underlying diseases,long term using of broad spectrum antibiotics and treated by ventilator.Clinical features included cough(62cases91.2%),expectoration(58cases85.3%)and fever(45cases66.2%).Chest X-ray represented lower infiltration in low lobes of lungs and crassitude of lung markings.The antibiotic susceptibility studies showed that the rates of resistance to ampicillin,amoxicillin/clavulanate,cefazolin,cefuroxime and piperacillin were higher,while the rates of susˉceptibility to imipenem,cefoperazone/suobactam,amikacin,and ceftazidime were higher,especiallly the rate of susceptibility to imipenem was the highest(98.0%).Conclusion:Lower respiretory tract infection by Esˉcherichia Coli has no clinical characteristics.The diagnosis and treatment depend on the results of microbial culture and the microbial drug-sensitivity test.Imipenem,cefoperazone/suobactam,amikacin,and cefˉtazidime have been the most efficacious antibiotics in the treatment of lower respiratory tract infection by Esˉcherichia Coli.