Transsphenoidal surgery on pituitary Cushing's disease: efficiency evaluation

Objective To investigate the effect of transsphenoidal surgery for the Cushing's disease. Methods A total of 122 patients with Cushing's disease admitted in our department from January 2009 to November 2012 were analyzed retrospectively. Pre-operative and post-operative hormonal levels were tested. Results The remission rate was 90. 9%. There is a significant difference between remission group and non- remission group in the plasma cortisol levels at different time points post-operatively.( P 0. 05),however, 24 h urinary free cortisol level just at the time of 1 to 2 d and 3 ～ 6 months post-operation showed significant differences( P 0. 05). Conclusion Transsphenoidal surgery is an effective method for the treatment of Cushing's disease. After transsphenoidal surgery,the prognosis can be judged by post-operative plasma cortisol level,24 h urinary free cortisol level and adrenocoticotropic hormone level.