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2010•Unpublished venueRequires access

Effects of Kakkonein on the Protein Expression of Bcl-2 and Bax in Rat Retina after Acute Injury

Cui Chen

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Abstract

Objective To study the effects of kakkonein on the protein expression of Bcl-2 and Bax in rat retina after acute intraocular hypertension.Methods After acute intraocular hypertension,changes in protein expression of Bcl-2 and Bax were detected by immunohistochemical method.Results In group A,there is positive expression of Bcl-2 and Bax protein.In group B,the level of positive expression of Bcl-2 and Bax protein was increased from 12h to 48h,and there is statistical difference as compared to group A(P﹤0.01).There was statistical difference on the expression of Bcl-2 and Bax between Group B and C from 12h to 48h(P﹤0.05).Conclusion The protein expression of Bcl-2 and Bax was increased in rat retina after acute intraocular hypertension and kakkonein could upregulate Bcl-2 expression and downregulate Bax expression.

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Objective To study the effects of kakkonein on the protein expression of Bcl-2 and Bax in rat retina after acute intraocular hypertension.Methods After acute intraocular hypertension,changes in protein expression of Bcl-2 and Bax were detected by immunohistochemical method.Results In group A,there is positive expression of Bcl-2 and Bax protein.In group B,the level of positive expression of Bcl-2 and Bax protein was increased from 12h to 48h,and there is statistical difference as compared to group A(P﹤0.01).There was statistical difference on the expression of Bcl-2 and Bax between Group B and C from 12h to 48h(P﹤0.05).Conclusion The protein expression of Bcl-2 and Bax was increased in rat retina after acute intraocular hypertension and kakkonein could upregulate Bcl-2 expression and downregulate Bax expression.

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Available abstract

Objective To study the effects of kakkonein on the protein expression of Bcl-2 and Bax in rat retina after acute intraocular hypertension.Methods After acute intraocular hypertension,changes in protein expression of Bcl-2 and Bax were detected by immunohistochemical method.Results In group A,there is positive expression of Bcl-2 and Bax protein.In group B,the level of positive expression of Bcl-2 and Bax protein was increased from 12h to 48h,and there is statistical difference as compared to group A(P﹤0.01).There was statistical difference on the expression of Bcl-2 and Bax between Group B and C from 12h to 48h(P﹤0.05).Conclusion The protein expression of Bcl-2 and Bax was increased in rat retina after acute intraocular hypertension and kakkonein could upregulate Bcl-2 expression and downregulate Bax expression.

Key concepts: BAX Protein, Immunohistochemistry, Downregulation and upregulation, Retina, Protein expression, Apoptosis, Bcl-2-associated X protein, Medicine

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Effects of Kakkonein on the Protein Expression of Bcl-2 and Bax in Rat Retina after Acute Injury — Research Paper | ScholarLens