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2008•Acta Academiae Medicinae XuzhouRequires access

The overexpression and clinical significance of hypoxia-inducible factor-1 alpha and carbonic anhydrase IX in renal cell carcinoma

Xue Song

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Abstract

Objective To investigate the expression of HIF-1α and CAⅨ in renal cell carcinoma(RCC) and to evaluate their significance.Methods The expressions of HIF-1α and CAⅨ were tested by immunohistochemistry in 54 specimens of RCC tissue,with the results analyzed by relating them to the clinical stage and pathological grade.Results The HIF-1α expression in RCC tissue was 55.6%,not related to the histological type(P0.05),but related to the clinical stage and pathological grade of RCC(P0.05).The CAⅨ expression in RCC tissue was 68.5% positive,not related to the histological type,pathological grade or clinical stage of RCC(P0.05).The expression of HIF-1α was positively correlated with the expression of CAⅨ(r=0.437,P=0.001).Conclusion The overexpression and high correlation of HIF-1α and CAⅨ in renal cell carcinoma support the feasibility of using targeted molecular therapy to treat RCC.

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Objective To investigate the expression of HIF-1α and CAⅨ in renal cell carcinoma(RCC) and to evaluate their significance.Methods The expressions of HIF-1α and CAⅨ were tested by immunohistochemistry in 54 specimens of RCC tissue,with the results analyzed by relating them to the clinical stage and pathological grade.Results The HIF-1α expression in RCC tissue was 55.6%,not related to the histological type(P0.05),but related to the clinical stage and pathological grade of RCC(P0.05).The CAⅨ expression in RCC tissue was 68.5% positive,not related to the histological type,pathological grade or clinical stage of RCC(P0.05).The expression of HIF-1α was positively correlated with the expression of CAⅨ(r=0.437,P=0.001).Conclusion The overexpression and high correlation of HIF-1α and CAⅨ in renal cell carcinoma support the feasibility of using targeted molecular therapy to treat RCC.

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Available abstract

Objective To investigate the expression of HIF-1α and CAⅨ in renal cell carcinoma(RCC) and to evaluate their significance.Methods The expressions of HIF-1α and CAⅨ were tested by immunohistochemistry in 54 specimens of RCC tissue,with the results analyzed by relating them to the clinical stage and pathological grade.Results The HIF-1α expression in RCC tissue was 55.6%,not related to the histological type(P0.05),but related to the clinical stage and pathological grade of RCC(P0.05).The CAⅨ expression in RCC tissue was 68.5% positive,not related to the histological type,pathological grade or clinical stage of RCC(P0.05).The expression of HIF-1α was positively correlated with the expression of CAⅨ(r=0.437,P=0.001).Conclusion The overexpression and high correlation of HIF-1α and CAⅨ in renal cell carcinoma support the feasibility of using targeted molecular therapy to treat RCC.

Key concepts: Renal cell carcinoma, Immunohistochemistry, Pathological, Clinical significance, Hypoxia-inducible factors, Stage (stratigraphy), Carcinoma, Pathology

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The overexpression and clinical significance of hypoxia-inducible factor-1 alpha and carbonic anhydrase IX in renal cell carcinoma — Research Paper | ScholarLens