2010•Liaoning zhongyi zazhiRequires access
The Influence of Electroacupuncture Therapy on the Expression of Hippocampus BDNF,TrkB in Rats Model of Alzheimer′s Disease
Yu-he Cheng
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Abstract
Objective:To observe the influence of electroacupuncture therapy on the expression of hippocampus BDNF,TrkB in rats model of Alzheimer′s disease.Methods:All animals were randomly divided into four groups:normal group,sham-operation group,model group,electroacupuncture group.AD rats were induced by injecting β-Amyloid 25-35(Aβ_25-35)into the double hippocampus.Meanwhile,Fengfu point was acupunctured in electroacupuncture group.A behavioral examination was made by Morris Water-Maze.Immunohistochemistry was used to detect the expression of the hippocampus BDNF,TrkB.Results:Rats′ learning and memory abilities of model group were significantly lower than that of normal group and electroacupuncture group(P0.01);the expression of BDNF,TrkB in rat hippocampus of model group were significantly lower than that of normal group(P0.01)and electroacupuncture group(P0.01).Conclusion:Acupuncture in Fengfu point can increase the expression of hippocampus BDNF and TrkB and thereby prevent a decline in learning and memory abilities in AD rats.