Clinical treatment and analysis of uveitis associated with ankylosing spondylitis

Objective To investigate the clinical characteristics and diagnosis of uveitis associated with ankylosing spondylitis(AS),and to analyze the treatment and prognosis of the disease.Methods The clinical,laboratory and treatment data of 19 patients with uveitis associated AS were analyzed retrospectively.Patients suffering from uveitis associated with AS were observed and analyzed.Results The age of the patients at onset of AS was 11～42(27±11) years old,and was 13～46(29±12) years old.There were 12 patients who had been diagnosed as AS before they went to see ophthalmologist,and 7 patients with first-diagnosis records as ocular uveitis who were diagnosed as AS later.Uveitis history was 4 days ～5 years;course was 14～37 days;average course was(27±7) days.Thirteen patients had clear history of recurrence of uveitis.All cases had typical definitely radiological evidences of sacroiliitis.HLA-B27 of 15(78.9%) cases were positive,12 cases(63.2%) were elevated erythrocyte sedimentation rate,7 cases(36.8%) were CRP10 mg/L.All cases were improved after treated with corticosteroids and cycloplegic agent eyedrops.Conclusion Uveitis associated with AS is usually involved young males.The disease is often unilateral onset and easy to relapse. Diagnosis could be made according to typical clinical features and radiological evidences.Patients could get good results if they got effective treatment.