2003•Zhongguo yaolixue tongbaoRequires access

Effects of mitochondrial ATP-sensitive potassium channel opener on the structures and functions of the mitochondria

Hao Wang

Abstract

AIM To evaluate the effects of diazoxide on the structures and functions of the mitochondria after hypoxia injury. METHODS A myocardial hypoxia injury model on rat is established by subcutaneous injection of isoproterenol (ISO) 5 mg·kg -1. The degree of oxidative phosphorylation, membrane lipid fluidity (LFU), phospholipidase A 2 activity, and phosphlipid content of mitochondria were observed after hypoxia injury. RESULTS Compared with the controls, the levels of RCR, LFU and phosphlipid content were decreased 20.8% (P0.01), 9.1% and 37.5% (P0.05), respectively. PLA 2 were increased by 144.5%(P0.01). Administration of diazoxide increased RCR, LFU and phosphlipid content. CONCLUSION These results suggest that diazoxide has a protective effect on ISO-induced myocardial injury in rats.

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Key concepts: Diazoxide, Mitochondrion, Potassium channel opener, Hypoxia (environmental), Potassium channel, Potassium, Oxidative phosphorylation, Chemistry