In Vitro Antibacterial Activity of Cefoperazone/Tazobactam

Objective To study the in vitro antibacterial activity of cefoperazone in combination with tazobactam against 211 strains of clinically isolated pathogenic bacteria.Methods The antibacterial activity of cefoperazone /tazobactam(4∶1) against 291 strains of clinically isolated pathogenic bacteria in vitro were detected by two fold agar dilution method and compared with cefoperazone, cefoperazone /sulbactam(2∶1) and piperacillin /tazobactam(8∶1). Results The antibacterial activity of cefoperazone in combination with tazobactam was superior to cefoperazone and piperacillin /tazobactam(8∶1),and similar to cefoperazone/sulbactam(2∶1). Conclusion The stability of cefoperazone /tazobactam(4∶1) to β-lactamases was improved and the antibacterial activity of cefoperazone were enhanced by tazobactam.