The changes in the bone mineral density and the associated factors in male T2DM patients

Objective To study the changes of level of bone mineral density(BMD)in male T2DM patients and analyze the main factors that influence BMD. Methods The subjects of this study were 156male T2DM patients and 104healthy men(NC).BMI25kg/m2 was as non-obese group,and≥25kg/m2 as obese group.Subgroups included A(T2DM +non-OB),C(T2DM + OB),B(NC+non-OB)and D(NC+OB).The BMD at the femoral neck and its T score were measured.The difference between the two groups was analyzed and the related factors of BMD in the male T2DM patients were studied. Results(1)The BMD level showed no significantly statistical difference between subgroup A and C,between subgroup B and D,between DM and NC.(2)The BMD level of male T2DM patients was positively correlated with body weight,BMI,and WC,but negatively correlated with Cr.There was no relation of the BMD level of male T2DM patients with age,HbA1c,TC,LDL-C,and duration of diabetes.The stepwise regression analysis demonstrated that BMI was the strongest predictor of BMD in male T2DM patients(r2=0.361,P0.05). Conclusion In males,there is no relation between T2DM and BMD at the femoral neck.