2006•Chinese Journal of Critical Care MedicineRequires access

Changes of myocardial ultrastructure and effects of Ulinastatin in rats after CPR

Lu Yi

Abstract

Objective To study the changes of myocardial uhrastructure and effects of Ulinastatin(UTI)on rats after cardiop- ulmonary resuscitation(CPR),and to investigate their mechanism.Methods Wistar rats were randomly divided into three groups: sham control group;routine treatment group;UTI treatment group(n=8,per group).Cardiac arrest was induced by asphyxiation in groups except A and CPR was performed.Two hours after recovery,arterial blood was drew for determination of serum TNF-αand CK-MB.The ultrastructural damages were observed with transmission electron microscope(TEM).Results Compared with routine treatment group,serum level of TNF-αin UTI treatment group decreased significantly and heart function improved.The damage of myocardial ultrastructure was ameliorated markedly.Conclusions TNF-αis probably the extremely important factors that promote the myocardial injury.Ulinastatin can improve the heart function of rats during early stage of resuscitation,and may alleviate the myo- cardial injury.

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Key concepts: Ulinastatin, Medicine, Resuscitation, Anesthesia, Cardiac function curve, Ultrastructure, Internal medicine, Cardiology