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2008•Journal of Clinical StomatologyRequires access

Expression of HBD-2 in saliva of oral diseases

Zhou Zeng-ton

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Abstract

Objective: Human beta defensins play a important role for their antimicrobial activity in mucosa immune system. This study aims to detect human beta defensin 2 in whole unstimulated saliva(WUS) of oral lichen planus(OLP), oral leukoplakia(OLK)and oral candidiasis. Method:The WUS samples were collected in a group of 40 patients (18 men, 22 women) with 20 cases of OLP,10 cases of OLK,10 cases of oral candidiasis,age range 20～55 years. Control group consisted of 20 healhy controls, mean age 25 years. Saliva beta defensin 2 was detected by Western Blotting. Result:HBD-2 was detected in 12/20 controls and all patients which was higher than that in controls. Conclusion:These results show that the change of HBD-2 in oral diseases reflects the infection degree,but also indicate that there maybe relationship between human beta defensins and pre-malignant diseases.

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What this paper is about

Objective: Human beta defensins play a important role for their antimicrobial activity in mucosa immune system. This study aims to detect human beta defensin 2 in whole unstimulated saliva(WUS) of oral lichen planus(OLP), oral leukoplakia(OLK)and oral candidiasis. Method:The WUS samples were collected in a group of 40 patients (18 men, 22 women) with 20 cases of OLP,10 cases of OLK,10 cases of oral candidiasis,age range 20～55 years. Control group consisted of 20 healhy controls, mean age 25 years. Saliva beta defensin 2 was detected by Western Blotting. Result:HBD-2 was detected in 12/20 controls and all patients which was higher than that in controls. Conclusion:These results show that the change of HBD-2 in oral diseases reflects the infection degree,but also indicate that there maybe relationship between human beta defensins and pre-malignant diseases.

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Available abstract

Objective: Human beta defensins play a important role for their antimicrobial activity in mucosa immune system. This study aims to detect human beta defensin 2 in whole unstimulated saliva(WUS) of oral lichen planus(OLP), oral leukoplakia(OLK)and oral candidiasis. Method:The WUS samples were collected in a group of 40 patients (18 men, 22 women) with 20 cases of OLP,10 cases of OLK,10 cases of oral candidiasis,age range 20～55 years. Control group consisted of 20 healhy controls, mean age 25 years. Saliva beta defensin 2 was detected by Western Blotting. Result:HBD-2 was detected in 12/20 controls and all patients which was higher than that in controls. Conclusion:These results show that the change of HBD-2 in oral diseases reflects the infection degree,but also indicate that there maybe relationship between human beta defensins and pre-malignant diseases.

Key concepts: Saliva, Oral lichen planus, Oral mucosa, Beta defensin, Defensin, Medicine, Leukoplakia, Gastroenterology

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