Effects of lovastatin on proliferation function of BRCA1-transfected breast cancer cells

Objective To study the effect of cholesterol inhibitor-lovastatin on the proliferation function of BRCA1-transfected MCF-7 breast cancer cells.Methods BRCA1 gene overexpressing MCF-7 human breast cancer cell (MCF-7 BRCA1) were generated by gene transfecting technique.After being treated with 8μmol/L lovastatin for 1-3d,the proliferation of nontransfected (MCF-7) cells and BRCA-1-transfected (MCF-7 BRCA1) cell were analyzed by growth curve,MTT and transmission electron microscope.Results Lovastatin could inhibit the proliferation of MCF-7 cells and MCF-7 BRCA1 cells,but the changes was more obviously in MCF-7 BRCA1 cells than MCF-7 cells.Meanwhile,lovastatin could significantly induce the differentiation of MCF-7 BRCA1 cells.Conclusion The overexpression of BRCA1 gene in MCF-7 cells could enhance the funcion of inhibiting cells proliferation by lovastatin.