Tian Xiao-pen
Abstract
Ethyl 4,4-difluoroacetoacetate was synthesized from ethyl acetate and 4,4-difluoroacetoacetate(mole ratio 3∶1) with sodium ethylate.The reaction was carried at 50℃ for 4 hours.Ethanol from the reaction was removed by distilling the azeotropic of ethyl acetate and ethanol to complete the reaction.The yield was 68.14% with purity no less than 99%.
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Ethyl 4,4-difluoroacetoacetate was synthesized from ethyl acetate and 4,4-difluoroacetoacetate(mole ratio 3∶1) with sodium ethylate.The reaction was carried at 50℃ for 4 hours.Ethanol from the reaction was removed by distilling the azeotropic of ethyl acetate and ethanol to complete the reaction.The yield was 68.14% with purity no less than 99%.
Key concepts: Ethyl acetate, Ethanol, Chemistry, Yield (engineering), Organic chemistry, Sodium acetate, Nuclear chemistry, Materials science