Advance in Reverse Genetics Technology of Foot-and-mouth Disease Virus

Foot-and-mouth disease(FMD)is an infectious disease caused by foot-and-mouth disease virus(FMDV).Office International Des Epizooties(OIE)has listed foot-and-mouth disease as the first disease of the most important animal epidemic diseases.If FMD breaks out,it shall seriously affect the development of animal husbandry,and the national economy.But now,we still have the blind spot for the footand-mouth disease virus' s understanding.There are many insufficiencies for the foot-and-mouth disease vaccine.The rapid development of viral reverse genetics technology has provided one new and effective technical method for the research of the foot-and-mouth disease virus structure and the research of the new vaccine and biological preparations.This article reviewed the domestic and foreign research of FMDV molecular pathogenic mechanism and the new FMD vaccine preparation by reverse genetics technology,at last prospected the new trend of foot-and-mouth disease virus reverse genetics.