Combined use of PCT,CRP and WBC to improves the sensitivity for the early diagnosis of neonatal pneumonia

Objective To investigate the application value of serum calcitonin original( PCT) and c-reactive protein( CRP)in the diagnosis of neonatal infectious pneumonia. Methods The PCT and CRP by electrochemical luminescence method,respectively,immune turbidimetric method to analyze the results; Statistical analysis including receiver operating characteristic( ROC) curve,the area under the curve( AUC),and logistic regression analysis was performed to evaluate the diagnostic value of these markers. Results Bacterial infection group with the WBC,PCT and CRP significantly higher than the virus infection group and healthy group( P 0. 05); Virus infection group compared with healthy group,there was no statistically significant difference( P 0. 05). The sensitivity of WBC,PCT and CRP in bacterial infection group was 67. 4%,80. 4%,67. 4%,individually,and increased to 96. 7% in combination. By using the optimal cut-off value,the sensitivity of WBC,PCT,CRP was88. 0%,80. 4%,80. 4%,individually. However,the specificity decreased to 92. 1% from 98. 9%. Conclusion CRP and PCT test are the differential diagnosis of neonatal good indicator bacteria and virus infectious diseases. Also the diagnosis of systemic bacterial infection has good sensitivity and specificity. The testing results of the serum PCT can provide a basis for clinicians timely adjustment of antimicrobial agents.