ScholarLens Back to search
2007•Hebei yiyaoRequires access

Expression of Ki-67 and P53 protein in high-differentiated chondrosarcoma and chondroma tissues

Feng Gao

Open publisher page 0 citations

Abstract

Objective To investigate the expression of Ki-67 and P53 protein in high-differentiated chondrosarcoma and chondroma tissues.Methods The expression of Ki-67 and P53 protein in 38 specimens of high-differentiated chondrosarcoma and 15 specimens of chondroma were detected by SP immunohistochemistry.Results The protein levels of Ki-67 and P53 were significantly higher in high-differentiated chondrosarcoma than those of chondroma(3.56±1.23,4.21±1.52 vs 0.75±0.46,0.87±0.43,(P0.05),the Ki-67 expression was positively correlated to P53 expression(P0.05).Conclusion The expressions of Ki-67 and P53 protein are significantly higher in high-differentiated chondrosarcoma than those in chondroma,to examine the expression of Ki-67 and P53 protein may be useful to the diagnosis and differential diagnosis of high-differentiated chondrosarcoma and chondroma.

About this research paper

What this paper is about

Objective To investigate the expression of Ki-67 and P53 protein in high-differentiated chondrosarcoma and chondroma tissues.Methods The expression of Ki-67 and P53 protein in 38 specimens of high-differentiated chondrosarcoma and 15 specimens of chondroma were detected by SP immunohistochemistry.Results The protein levels of Ki-67 and P53 were significantly higher in high-differentiated chondrosarcoma than those of chondroma(3.56±1.23,4.21±1.52 vs 0.75±0.46,0.87±0.43,(P0.05),the Ki-67 expression was positively correlated to P53 expression(P0.05).Conclusion The expressions of Ki-67 and P53 protein are significantly higher in high-differentiated chondrosarcoma than those in chondroma,to examine the expression of Ki-67 and P53 protein may be useful to the diagnosis and differential diagnosis of high-differentiated chondrosarcoma and chondroma.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the expression of Ki-67 and P53 protein in high-differentiated chondrosarcoma and chondroma tissues.Methods The expression of Ki-67 and P53 protein in 38 specimens of high-differentiated chondrosarcoma and 15 specimens of chondroma were detected by SP immunohistochemistry.Results The protein levels of Ki-67 and P53 were significantly higher in high-differentiated chondrosarcoma than those of chondroma(3.56±1.23,4.21±1.52 vs 0.75±0.46,0.87±0.43,(P0.05),the Ki-67 expression was positively correlated to P53 expression(P0.05).Conclusion The expressions of Ki-67 and P53 protein are significantly higher in high-differentiated chondrosarcoma than those in chondroma,to examine the expression of Ki-67 and P53 protein may be useful to the diagnosis and differential diagnosis of high-differentiated chondrosarcoma and chondroma.

Key concepts: Chondroma, Chondrosarcoma, Immunohistochemistry, P53 protein, Medicine, Pathology, Protein expression, Ki-67

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of Ki-67 and P53 protein in high-differentiated chondrosarcoma and chondroma tissues — Research Paper | ScholarLens