Effect of amiodarone plus losartan in treatment of atrial fibrillation

This paper is to observe the effect of oral amiodarone plus losartan in treatment of patients with sinus rhythm atrial fibrillation(AF). Thirty six patients with AF received amiodarone plus losartan treatment were analyzed retrospectively. Sixty patients with AF received amiodarone were taken as control group. After 3 weeks, the remainder of the patients with AF in 2 groups went on to have electric cardioversion. After electric cardioversion, the patients continued drugs treatment in both groups and were followed up for 1 year. There was no marked difference in cardioversion efficacy between 2 groups with chemical cardioversion and electric cardioversion. There was no marked difference between 2 groups with chemical cardioversion in the maintenance of normal sinus rhythm after 1 12 months, but there was significant difference between 2 groups with electric cardioversion in the maintenance of normal sinus rhythm after 12 months ( P 0.05). Amiodarone plus losartan is better than amiodarone alone for AF patients received electrical cardioversion in maintaining normal sinus rhythm in a long term.