Clinical observation of dexmedetomidine for patients undergoing neurosurgery general anesthesia to prevent postoperative agitation

Objective To observe the preventive effect of dexmedetomidine on postoperative agitation with patients undergoing neurosurgery general anesthesia. Methods Sixty patients undergoing neurosurgery general anesthesia were randomly divided into two groups:group dexmedetomidine(group D),and control group(group C).Anesthetics were stopped 10 min before the end of operation. Patients in group D was given dexmedetomidine(0.4 μg /kg )intravenously, while in group C was equal volume of saline.Hemodynamic changes were recorded before anesthesia,at the moment of extubation and 5 min after extubation respectively.The incidence of agitation and sedation scores were assessed at 5,30,60,120 min after extubation. The breathing recovery time, arousing time and extubation time were observed.Results MAP and HR were significantly decreased in group D than in group C at the moment of extubation and 5 min after extubation(P0.05).Compared with before anesthesia, MAP was decreased and HR became slower significantly in group D at 5 min after extubation. MAP was increased and HR became faster in group C on the moment of extubation and 5 min after extubation (P0.05). Compared with group C,the agitation incidence and level were lower in group D.The score of VAS were lower at 5,30,60,120 min after extubation and the score of Ramsay were higher at 5,30 min after extubation in group D than in group C (P0.05).Conclusion The injection of dexmedetomidine (0.4 μg /kg) with minipump can suppress extubation stress and relieve agitation, while did not prolong the breathing recovery time,arousing time and extubation time.Dexmedetomidine can prevent postoperative agitation of neurosurgery after general anesthesia.