Relationship Among Plasma Brain Natriuretic Peptide(BNP) Levels,Left Ventricular Ejection Fraction(LVEF) and Left Ventricular End-Diastolic Diameter(LVEDD) in Patients with Heart Failure

Objective To investigate the level differences of plasma brain natriuretic peptide(BNP) in patients with chronic stable and decompensation heart failure and their relationship among BNP,left ventricular ejection fraction(LVEF) and left ventricular end-diastolic diameter(LVEDD).Methods Ninety-six patients with heart failure were examined by UCG after admission,and they were divided into three groups according to NYHA's heart function class criterion:NYHA class Ⅱ group 40 cases,including chronic stable heart failure 14 cases;decompensation heart failure 26 cases;NYHA class Ⅲ group 40 cases;including chronic stable heart failure 16 cases;decompensation heart failure 24 cases;NYHA class Ⅳ group 16 cases,including chronic stable heart failure 4 cases;heart failure 12 cases.The concentration of BNP was measured by Achitect I2000SR full-automatic chemiluminesent immunoassay(CLIA).Results The concentration of BNP between NYHA class Ⅱ,Ⅲ,Ⅳ groups(include chronic stable and decompensation groups) had significant differences(P0.05);LVEED and LVEF between NYHA class Ⅱ,Ⅲ,Ⅳ groups in chronic stable groups had significant differences(P0.05);but had no significant differences between decompensation groups(P0.05).Conclusion The level of BNP and NYHA classes had a positive relationship,had positive relationship between LVEED and LVEF and NYHA classes in stable heart failure groups,had no relationship between LVEED and LVEF and NYHA classes in decompensation heart failure groups.